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KMID : 1134820160450101430
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 10 p.1430 ~ p.1437
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Isoflavone Composition and Estrogenic Activity of Germinated Soybeans (Glycine max) according to Variety
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Kim Min-Young
Jang Gwi-Yeong
Ji Yeong-Mi
Kim Kyung-Mi
Kim Hong-Sig
Lee Jun-Soo
Jeong Heon-Sang
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Abstract
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This study was performed to investigate the changes in isoflavone composition, estrogenic activity and antiestrogenic activity of soybean cultivars of different isoflavone content (Aga 8, Uram, Cheongja 3, and Dawon) with germination. Total isoflavone contents of Aga 8, Dawon and Cheongja 3 was increased from 2,671.74, 261.08 and 2,240.08 to 2,977.50, 966.13 and 2,354.11 μg/g, respectively after germination except for Uram cultivars, and highest contents of total isoflavone showed 2,977.50 μg/g and 2,354.11 μg/g, respectively in Aga 8 and Cheongja 3 after germination. MTT cell proliferation assay using MCF-7 cells revealed that germinated soybean of Aga 8 and Cheonja 3 obtained not only contained a high content of isoflavone but also had estrogenic activity. Estrogenic activity of Aga 8 and Cheongja 3 soybean extracts increased from 116.21% and 101.60% to 135.34% and 121.05% after germination. These results suggest that germinated soybean of Aga 8 and Cheongja 3 might have a potential preventive effect on estrogen-deficient diseases.
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KEYWORD
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soybean, varieties, germination, isoflavone, estrogenic activity
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